NM_004655.4:c.1908-23C>T is a deep intronic variant in AXIN2 located 23 bp upstream of exon 7. SpliceAI predicts no splicing impact for this variant (max delta score = 0.00), providing no computational evidence of altered splicing.¹ The variant is present in gnomAD at extremely low frequency: v2.1 AF = 0.00109% (3/274,000 alleles) and v4.1 AF = 0.00037% (6/1,611,554 alleles), with no homozygotes observed (PM2_supporting). However, rarity alone is limited by the absence of a predicted functional consequence.² This variant is absent from ClinVar, and no publications, functional studies, segregation data, or de novo observations are available.³ AXIN2 loss of function is a recognized germline disease mechanism associated with colorectal polyposis and tooth agenesis, but no variant-specific evidence exists to support pathogenicity of this deep intronic substitution.⁴ Based on the generic ACMG/AMP 2015 classification framework, the available evidence (PM2_supporting only) is insufficient to classify this variant as pathogenic or likely pathogenic. The variant is classified as a Variant of Uncertain Significance (VUS).⁵