NM_000261.2:c.719A>G (p.Glu240Gly) in MYOC is a rare missense variant absent from gnomAD v2.1 and present at extremely low frequency in gnomAD v4.1 (AF = 3.72e-06, 6/1,614,146 alleles), meeting PM2 at supporting strength per the ClinGen Glaucoma VCEP v2.1.¹ The REVEL score of 0.205 falls within the VCEP BP4 supporting range (0.184-0.290), and SpliceAI predicts no splice impact (max delta = 0.01), meeting BP4 at supporting strength.² This variant has been reported in ClinVar as Uncertain Significance by the ClinGen Glaucoma Variant Curation Expert Panel (ClinVar ID 2442275, reviewed by expert panel).³ No functional studies, de novo reports, proband counts, or segregation data were identified for this variant in the available literature. PS1, PS2, PS3, PS4, PP1, and BS3 remain not assessed due to absence of data. Under the Glaucoma VCEP v2.1 point-based scoring system, the variant accumulates +1 point (PM2_supporting) and -1 point (BP4_supporting), yielding a total of 0 points, which falls within the Uncertain Significance range (-1 to 5 points).⁴