NM_000267.3:c.2355A>G (p.Glu785=) is a synonymous variant in NF1 with no predicted splice impact (SpliceAI max delta 0.00).¹ The variant is present in gnomAD v2.1 at a frequency of 0.00141% (4/282,792 alleles) and in gnomAD v4.1 at 0.00235% (38/1,613,806 alleles), with no homozygotes observed.² ClinVar classifies this variant as Likely benign (Variation ID 230539) based on submissions from 5 clinical laboratories, with a review status of criteria provided, single submitter (1-star).³ No publications directly mention or provide variant-specific evidence for NM_000267.3:c.2355A>G; literature review of available full-text articles (PMID: 25741868, 17636453, 25394175, 26324357) confirmed this variant is not cited in any publication.⁴ BP7 is met at supporting strength: this synonymous variant is predicted to have no splice impact by SpliceAI and is present in population databases, consistent with a non-conserved, likely benign nucleotide position.⁵ No pathogenic criteria are met. No benign criteria beyond BP7 are met. The ClinVar Likely benign classification is consistent with the evidence that this synonymous variant lacks functional consequence.⁶