NM_000455.5:c.920+12C>T is an intronic variant in STK11 located 12 base pairs downstream of exon 7. This variant is present in gnomAD at low frequency across multiple populations (0.006% overall in v2.1, 0.003% in v4.1), with the highest subpopulation frequency of 0.046% in the African/African American population, indicating it is a rare but known variant and not absent from population databases.¹ SpliceAI predicts no splicing impact (max delta score = 0.00), providing computational evidence against a deleterious splicing effect for this intronic variant (BP4_supporting).² ClinVar classifies this variant as Likely benign based on 4 clinical laboratory submissions, though the review status is 1-star (criteria provided, single submitter), which does not reach the expert panel threshold for BP6 application.³ No functional studies, de novo reports, segregation data, case-control studies, or variant-specific literature are available for this variant. The variant has not been reported in COSMIC and is not listed as a cancer hotspot. Based on the available evidence, only BP4 (supporting benign) is met. The overall evidence is insufficient to classify this variant as benign or likely benign; the variant remains a variant of uncertain significance (VUS) with a single supporting benign criterion.⁴