All three requested criteria are not applicable because NM_000546.6:c.-89A>G is a 5′-UTR single-nucleotide variant with p.? and no qualifying protein-length or null-variant consequence. The governing TP53 VCEP PVS1 files were searched for c.-89A>G and the requested p.? notations; no exact pre-assigned entry was found. The ClinGen TP53 VCEP v2.4 framework governs all four requested criteria. PS2, PP1, and BS4 cannot be assessed because the case contains no proband, parental, pedigree, relative-genotype, phenotype, or meiosis evidence. PM6 is not applicable because the TP53 VCEP explicitly dropped PM6 and directs de novo evidence to PS2. The governing Table-of-LFS-Cancers-and-Points-for-PS2-and-PP1-Code-Application.pdf was searched under c.-89A>G, c.89A>G, p.Asn30Ser, and p.?; no variant-specific entry was found. All three requested computational criteria are not_applicable because NM_000546.6:c.-89A>G is a 5' UTR variant with protein consequence p.?, not a missense, synonymous, intronic, or splice-region variant within the applicable TP53 VCEP rules. The ClinGen TP53 VCEP v2.4 framework governs all four requested criteria. Population frequency evidence does not meet BA1, BS1, or PM2 because the relevant gnomAD v4.1 frequencies exceed the TP53 PM2 limit but remain below the TP53 BS1 and BA1 limits. BS2 is not assessable because no individual-level unaffected older female carrier data are available.