NM_000546.6:c.375+13G>A is an intronic variant in TP53 at position +13 of intron 4, outside the canonical splice consensus sequence. This variant is extremely rare in population databases, with an allele frequency of 3.72 x 10^-6 in gnomAD v4.1 (6/1,612,114 alleles), meeting TP53 VCEP PM2_Supporting.¹ SpliceAI predicts no splicing impact (max delta = 0.02), meeting TP53 VCEP BP4_Supporting and BP7_Supporting for intronic variants at or beyond +7 with SpliceAI ≤ 0.1.² This variant has been reported in ClinVar as Likely benign by 5 clinical laboratories (ClinVar ID 379461), though review status is 1-star (criteria provided, single submitter) and no 3-star expert panel classification exists.³ No functional data, segregation analysis, de novo observations, or case-control studies are available for this variant. The variant does not alter a protein-coding residue and is not eligible for PVS1, PS1, PS3, PM1, PM5, or BS3 under the TP53 VCEP framework. Under the TP53 VCEP v2.4 point-based system, applying PM2_Supporting (+1), BP4_Supporting (-1), and BP7_Supporting (-1) yields a total of -1 points. Per the VCEP caveat, when at least 2 benign evidence codes are applied and PM2_Supporting is the only pathogenic code, the classification may be overridden to Likely Benign.⁴