The RUNX1 NM_001001890.2:c.1036T>G (p.(Ser346Ala)) variant has not been observed in somatic cancers in COSMIC and has been reported in ClinVar as uncertain significance, including an expert panel submission from the ClinGen Myeloid Malignancy Variant Curation Expert Panel.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, which supports PM2_Supporting under the RUNX1 threshold of <=0.00005.² Computational evidence argues against a damaging effect because REVEL is 0.262, below the RUNX1 PP3 threshold and within the BP4 range, SpliceAI shows no predicted splice impact with a max delta score of 0.00, and BayesDel is -0.17459.³