The RUNX1 c.1132C>G (p.Leu378Val, p.L378V) variant has not been observed in somatic cancers in COSMIC and has been reported in ClinVar as Uncertain Significance, including an expert-panel submission from the ClinGen Myeloid Malignancy Variant Curation Expert Panel.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, which supports PM2_Supporting under the RUNX1 VCEP threshold of less than or equal to 0.00005.² Computational evidence supports a benign effect: REVEL is 0.323, below the RUNX1 BP4 cutoff of less than 0.50, SpliceAI max delta is 0.00, at or below the BP4 cutoff of 0.20, and BayesDel is negative at -0.252196.³