The BRAF c.739T>C (p.Phe247Leu) variant has not been observed in somatic cancers in COSMIC and has been reported in ClinVar as pathogenic, including by the ClinGen RASopathy Variant Curation Expert Panel.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, consistent with the BRAF RASopathy PM2_Supporting requirement for absence from population controls.² This missense change lies in BRAF exon 6, a region specifically designated by the BRAF RASopathy specification as eligible for PM1.³ Computational evidence supports a deleterious effect, with REVEL 0.902 above the BRAF RASopathy PP3 threshold of 0.7, BayesDel 0.278133, and SpliceAI showing no meaningful splice impact with a maximum delta score of 0.10.⁴