The BRAF c.793G>C (p.Gly265Arg) variant has been observed in somatic cancer once in COSMIC and has been reported in ClinVar with an expert panel likely pathogenic classification and additional pathogenic or likely pathogenic clinical laboratory submissions.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, supporting rarity in population reference datasets.² Computational evidence supports a damaging missense effect, with REVEL 0.917 above the BRAF RASopathy PP3 threshold of 0.7, BayesDel 0.403109 in a deleterious direction, and SpliceAI showing no significant predicted splice impact (maximum delta score 0.00).³