NM_002742.3:c.2130A>T (p.Glu710Asp) is a missense variant in exon 15 of PRKD1. This variant is absent from gnomAD v2.1, gnomAD v4.1, and gnomAD-Canada v1.0, meeting PM2 at moderate strength.¹ Missense variants in PRKD1 are an established germline disease mechanism (PMID:32817298 reports de novo p.Gly592Arg and p.Arg603His causing syndromic congenital heart disease with ectodermal dysplasia); BP1 does not apply. In silico predictors yield mixed results — REVEL 0.744 (damaging), BayesDel 0.117 (benign-leaning), SpliceAI 0.00 (neutral) — and do not meet the threshold for either PP3 or BP4.² No variant-specific functional data, de novo reports, cosegregation data, ClinVar classification, or case-control evidence are available for this variant.³ With only one moderate criterion (PM2) met and no supporting or pathogenic moderate criteria, the variant is classified as a Variant of Uncertain Significance (VUS) under generic ACMG/AMP 2015 combination rules.⁴