The FLT3 c.1794_1795insACCATTGATTTCAGAGAATATGAA (p.(Glu598_Tyr599insThrIleAspPheArgGluTyrGlu); p.(E598_Y599insTIDFREYE)) variant has not been observed in somatic cancers in COSMIC and has not been reported in ClinVar.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, which is below the default PM2 population threshold of 0.1%.² This variant affects the established FLT3 juxtamembrane ITD hotspot at codons 598 to 599; published studies showed recurrent constitutive activation for FLT3 ITDs in the codon 589 to 599 cluster, and OncoKB classifies this exact variant as Likely Oncogenic with a Likely Gain-of-function effect.³ SpliceAI predicts no significant splice impact for this variant, with a maximum delta score of 0.06.⁴