NM_016507.4:c.2351G>A (p.Arg784Gln) in CDK12 is a missense variant absent from ClinVar and present at extremely low frequency in population databases (gnomAD v2.1: 3/275,404 alleles, AF 0.00109%; gnomAD v4.1: 18/1,609,482 alleles, AF 0.00112%), meeting PM2 at supporting strength.¹ Multiple computational predictors support a benign effect: REVEL score 0.075 (strongly benign), BayesDel score −0.516897 (benign), and SpliceAI max delta 0.01 (no predicted splicing impact), meeting BP4 at supporting benign strength.² No functional studies, de novo observations, segregation data, case-control data, or ClinVar classifications were available to support additional pathogenic or benign criteria.³ The variant is observed once somatically in COSMIC (COSV104713462) but this does not contribute to germline ACMG/AMP classification. The supporting pathogenic evidence (PM2) is balanced by supporting benign evidence (BP4). No other criteria are met. The variant is classified as a Variant of Uncertain Significance (VUS).⁴