NM_004456.4:c.1852-9A>C is an intronic variant in EZH2 located 9 bases upstream of exon 15, outside canonical splice consensus sites.¹ This variant is present in gnomAD at very low frequency (v2.1: 11/246,568 alleles, AF=0.0045%; v4.1: 73/1,608,258 alleles, AF=0.0045%) with no homozygotes observed. The allele frequency falls well below the 0.1% PM2 threshold (PM2_supporting).² SpliceAI predicts no significant splice impact (max delta score = 0.02), providing computational evidence that the variant does not disrupt normal splicing (BP4_supporting).³ ClinVar classifies this variant as Likely benign (VariationID 416828) based on a submission from Labcorp Genetics with ACMG criteria provided. This constitutes supporting benign evidence from a reputable clinical source (BP6_supporting).⁴ PVS1 is not applicable as the variant lies outside canonical splice ±1,2 consensus sites and does not fall into null-variant buckets per ClinGen SVI recommendations (PMC6185798). PM5, PP2, BP1, BP7 are not applicable as the variant is intronic, not missense or synonymous. BP3, PM3, PM4 were skipped per instruction as trivially not applicable.⁵ Applying generic ACMG/AMP 2015 final classification combination rules: two supporting benign criteria (BP4, BP6) are met, which reaches the threshold for Likely benign. One supporting pathogenic criterion (PM2) is also met but does not alter the Likely benign classification under the standard combination rules.⁶