NM_001127208.2:c.5651C>A (p.Thr1884Asn) is a missense variant in TET2, a gene with emerging germline disease association involving autoimmune lymphoproliferative syndrome-like phenotypes and hematologic malignancy. The variant is absent from gnomAD v2.1 and v4.1 (0/1,551,598 alleles) and gnomAD-Canada, meeting PM2 at moderate strength.¹ Multiple in silico tools predict a neutral or benign effect: BayesDel score is -0.27313 (benign), REVEL score is 0.302 (neutral), and SpliceAI delta is 0.00 (no splice impact), meeting BP4 at supporting benign strength.² The variant is absent from ClinVar and has not been classified by any expert panel. OncoKB reports an 'Unknown Oncogenic Effect' with no variant-specific functional evidence.³ One somatic observation exists in COSMIC (COSV54403709, n=1), but this does not independently support germline pathogenicity. No functional studies, family segregation data, de novo observations, or case-control data are available. Literature search returned zero variant-specific PMIDs. With one moderate pathogenic criterion (PM2) and one supporting benign criterion (BP4), this variant does not meet the threshold for Likely Pathogenic (requires ≥2 moderate or ≥1 moderate + ≥4 supporting) or Likely Benign (requires ≥1 strong benign + ≥1 supporting benign, or ≥2 supporting benign). The variant is classified as a Variant of Uncertain Significance (VUS) under generic ACMG/AMP 2015 rules.⁴