Project HERA

MSH6 variants

Every MSH6 variant the pipeline has interpreted, classified against the ClinGen expert-panel specification for the gene where one exists.

44 variants

MSH6 variants

Newest first. Each row opens the full report, criterion by criterion.

44 shown
Variant
Protein change
Classification
MSH6 NM_000179.3:c.3674C>T
NP_000170.1:p.(T1225M)
VUS
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MSH6 NM_000179.3:c.2463A>C
NP_000170.1:p.(L821=)
Likely Benign
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MSH6 NM_000179.3:c.4002-16_4002-10del
NP_000170.1:p.?
VUS
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MSH6 NM_000179.2:c.3926C>A
NP_000170.1:p.(P1309Q)
VUS
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MSH6 NM_000179.2:c.2975A>G
NP_000170.1:p.(E992G)
VUS
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MSH6 NM_000179.3:c.2731C>T
NP_000170.1:p.(R911*)
Pathogenic
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MSH6 NM_000179.3:c.1403G>A
NP_000170.1:p.(R468H)
Likely Benign
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MSH6 NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
VUS
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MSH6 NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
VUS
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MSH6 NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
VUS
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MSH6 NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
VUS
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MSH6 NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
Likely Benign
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MSH6 NM_000179.3:c.1822A>G
NP_000170.1:p.(I608V)
VUS
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MSH6 NM_000179.2:c.1796G>A
NP_000170.1:p.(G599E)
—
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MSH6 NM_000179.2:c.1483C>T
NP_000170.1:p.(R495*)
Pathogenic
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MSH6 NM_000179.2:c.4068_4071dup
NP_000170.1:p.(K1358Dfs*2)
Benign
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MSH6 NM_000179.3:c.3602_3606delinsAA
NP_000170.1:p.(L1201_M1202delinsQ)
VUS
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MSH6 NM_000179.3:c.3162C>T
NP_000170.1:p.(I1054=)
Likely Benign
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MSH6 NM_000179.3:c.2526T>G
NP_000170.1:p.(A842=)
Likely Benign
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MSH6 NM_000179.3:c.3603C>A
NP_000170.1:p.(L1201=)
Likely Benign
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MSH6 NM_000179.3:c.533G>T
NP_000170.1:p.(R178L)
VUS
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MSH6 NM_000179.2:c.440T>G
NP_000170.1:p.(L147R)
VUS
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MSH6 NM_000179.3:c.643G>C
NP_000170.1:p.(V215L)
VUS
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MSH6 NM_000179.3:c.1054G>A
NP_000170.1:p.(V352I)
VUS
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MSH6 NM_000179.2:c.188C>T
NP_000170.1:p.(S63F)
VUS
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MSH6 NM_000179.2:c.3412G>A
NP_000170.1:p.(G1138R)
VUS
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MSH6 NM_000179.3:c.4002-26_4002-25insCT
NP_000170.1:p.?
Benign
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MSH6 NM_000179.3:c.4002-28_4002-26dup
NP_000170.1:p.?
Benign
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MSH6 NM_000179.3:c.260+21T>G
NP_000170.1:p.?
Likely Benign
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MSH6 NM_000179.3:c.1135_1139del
NP_000170.1:p.(R379*)
Pathogenic
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MSH6 NM_000179.3:c.3312del
NP_000170.1:p.(F1104Lfs*11)
Pathogenic
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MSH6 NM_000179.3:c.836G>A
NP_000170.1:p.(S279N)
VUS
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MSH6 NM_000179.3:c.4002-28_4002-26dup
NP_000170.1:p.?
Benign
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MSH6 NM_000179.3:c.3334G>A
NP_000170.1:p.(D1112N)
VUS
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MSH6 NM_000179.3:c.4002-17T>C
NP_000170.1:p.?
VUS
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MSH6 NM_000179.3:c.3261del
NP_000170.1:p.(F1088Sfs*2)
Pathogenic
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MSH6 NM_000179.3:c.-2G>T
NP_000170.1:p.?
VUS
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MSH6 NM_000179.3:c.3483T>C
NP_000170.1:p.(P1161=)
Likely Benign
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MSH6 NM_000179.3:c.866G>A
NP_000170.1:p.(G289D)
Likely Benign
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MSH6 NM_000179.3:c.2091T>C
NP_000170.1:p.(D697=)
Likely Benign
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MSH6 NM_000179.3:c.4T>A
NP_000170.1:p.(S2T)
VUS
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MSH6 NM_000179.3:c.3556+1G>C
NP_000170.1:p.?
VUS
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MSH6 NM_000179.3:c.199C>A
NP_000170.1:p.(P67T)
VUS
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MSH6 NM_000179.3:c.942C>G
NP_000170.1:p.(S314R)
VUS
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