Project HERA

TP53 variants

Every TP53 variant the pipeline has interpreted, classified against the ClinGen expert-panel specification for the gene where one exists.

81 variants

TP53 variants

Newest first. Each row opens the full report, criterion by criterion.

81 shown
Variant
Protein change
Classification
TP53 NM_000546.5:c.672+6G>A
NP_000537.3:p.?
VUS
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TP53 NM_000546.6:c.840A>C
NP_000537.3:p.(R280S)
Likely Pathogenic
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TP53 NM_000546.6:c.919+17A>G
NP_000537.3:p.?
VUS
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TP53 NM_000546.6:c.919+17A>G
NP_000537.3:p.?
Likely Benign
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TP53 NM_000546.6:c.840A>C
NP_000537.3:p.(R280S)
Likely Pathogenic
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TP53 NM_000546.6:c.820G>T
NP_000537.3:p.(V274F)
Likely Pathogenic
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TP53 NM_000546.6:c.599_600del
NP_000537.3:p.(N200Ifs*8)
Likely Pathogenic
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TP53 NM_000546.6:c.1118A>G
NP_000537.3:p.(K373R)
Likely Benign
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TP53 NM_000546.6:c.1118A>G
NP_000537.3:p.(K373R)
In progress — classification not generated yet.
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TP53 NM_000546.6:c.599_600del
NP_000537.3:p.(N200Ifs*8)
In progress — classification not generated yet.
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TP53 NM_000546.6:c.797G>T
NP_000537.3:p.(G266V)
VUS
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TP53 NM_000546.6:c.797G>T
NP_000537.3:p.(G266V)
VUS
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TP53 NM_000546.6:c.1001G>T
NP_000537.3:p.(G334V)
VUS
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TP53 NM_000546.6:c.266_267del
NP_000537.3:p.(P89Lfs*59)
Likely Pathogenic
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TP53 NM_000546.6:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
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TP53 NM_000546.6:c.266_267del
NP_000537.3:p.(P89Lfs*59)
Likely Pathogenic
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TP53 NM_000546.6:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
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TP53 NM_000546.6:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
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TP53 NM_000546.6:c.1154del
NP_000537.3:p.(F385Sfs*37)
VUS
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TP53 NM_000546.6:c.390C>T
NP_000537.3:p.(L130=)
Likely Benign
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TP53 NM_000546.6:c.375+13G>A
NP_000537.3:p.?
VUS
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TP53 NM_000546.5:c.612_623del
NP_000537.3:p.(E204_D207del)
VUS
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TP53 NM_000546.6:c.395A>T
NP_000537.3:p.(K132M)
Likely Pathogenic
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TP53 NM_000546.6:c.610G>T
NP_000537.3:p.(E204*)
Likely Pathogenic
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TP53 NM_000546.6:c.431_436del
NP_000537.3:p.(Q144_W146delinsR)
VUS
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TP53 NM_000546.5:c.580del
NP_000537.3:p.(I195Sfs*52)
Likely Pathogenic
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TP53 NM_000546.5:c.214C>T
NP_000537.3:p.(P72S)
VUS
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TP53 NM_000546.5:c.214_215delinsTG
NP_000537.3:p.(P72C)
VUS
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TP53 NM_000546.6:c.-29+102T>G
NP_000537.3:p.?
VUS
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TP53 NM_000546.6:c.-29+100dup
NP_000537.3:p.?
VUS
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TP53 NM_000546.5:c.520A>T
NP_000537.3:p.(R174W)
VUS
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TP53 NM_000546.6:c.-29+102T>G
NP_000537.3:p.?
In progress — classification not generated yet.
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TP53 NM_000546.5:c.684C>G
NP_000537.3:p.(D228E)
Likely Benign
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TP53 NM_000546.6:c.473G>T
NP_000537.3:p.(R158L)
Pathogenic
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TP53 NM_000546.6:c.-29+121G>T
NP_000537.3:p.?
VUS
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TP53 NM_000546.6:c.716A>G
NP_000537.3:p.(N239S)
Likely Pathogenic
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TP53 NM_000546.6:c.524G>A
NP_000537.3:p.(R175H)
Likely Pathogenic
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TP53 NM_000546.6:c.919+4A>G
NP_000537.3:p.?
VUS
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TP53 NM_000546.5:c.422G>A
NP_000537.3:p.(C141Y)
Likely Pathogenic
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TP53 NM_000546.5:c.833C>G
NP_000537.3:p.(P278R)
Likely Pathogenic
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TP53 NM_000546.6:c.700T>A
NP_000537.3:p.(Y234N)
Likely Pathogenic
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TP53 NM_000546.6:c.370T>C
NP_000537.3:p.(C124R)
Likely Pathogenic
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TP53 NM_000546.6:c.293C>G
NP_000537.3:p.(P98R)
VUS
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TP53 NM_000546.5:c.370T>C
NP_000537.3:p.(C124R)
Likely Pathogenic
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TP53 NM_000546.5:c.370T>G
NP_000537.3:p.(C124G)
VUS
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TP53 NM_000546.5:c.413C>A
NP_000537.3:p.(A138D)
VUS
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TP53 NM_000546.5:c.509C>T
NP_000537.3:p.(T170M)
VUS
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TP53 NM_000546.5:c.845G>T
NP_000537.3:p.(R282L)
VUS
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TP53 NM_000546.6:c.267del
NP_000537.3:p.(S90Pfs*33)
Likely Pathogenic
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TP53 NM_000546.6:c.832_839dup
NP_000537.3:p.(R280Sfs*68)
Likely Pathogenic
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TP53 NM_000546.5:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
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TP53 NM_000546.6:c.845G>A
NP_000537.3:p.(R282Q)
VUS
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TP53 NM_000546.6:c.469G>T
NP_000537.3:p.(V157F)
VUS
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TP53 NM_000546.5:c.319T>C
NP_000537.3:p.(Y107H)
Benign
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TP53 NM_000546.6:c.925C>T
NP_000537.3:p.(P309S)
—
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TP53 NM_000546.5:c.490A>G
NP_000537.3:p.(K164E)
Likely Pathogenic
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TP53 NM_000546.5:c.74+11C>T
NP_000537.3:p.?
VUS
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TP53 NM_000546.5:c.344A>G
NP_000537.3:p.(H115R)
Likely Benign
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TP53 NM_000546.6:c.587G>T
NP_000537.3:p.(R196L)
VUS
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TP53 NM_000546.5:c.840A>T
NP_000537.3:p.(R280S)
Likely Pathogenic
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TP53 NM_000546.5:c.1009C>T
NP_000537.3:p.(R337C)
Likely Pathogenic
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TP53 NM_000546.6:c.1010G>T
NP_000537.3:p.(R337L)
VUS
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TP53 NM_000546.6:c.1123C>A
NP_000537.3:p.(Q375K)
Likely Benign
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TP53 NM_000546.5:c.761T>C
NP_000537.3:p.(I254T)
Likely Pathogenic
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TP53 NM_000546.5:c.370T>A
NP_000537.3:p.(C124S)
Likely Benign
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TP53 NM_000546.5:c.1031T>C
NP_000537.3:p.(L344P)
Likely Pathogenic
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TP53 NM_000546.5:c.743G>T
NP_000537.3:p.(R248L)
Pathogenic
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TP53 NM_000546.5:c.1010G>C
NP_000537.3:p.(R337P)
Likely Pathogenic
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TP53 NM_000546.5:c.581T>G
NP_000537.3:p.(L194R)
Likely Pathogenic
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TP53 NM_000546.5:c.221C>T
NP_000537.3:p.(A74V)
Likely Benign
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TP53 NM_000546.6:c.374C>T
NP_000537.3:p.(T125M)
VUS
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TP53 NM_000546.5:c.1136G>T
NP_000537.3:p.(R379L)
VUS
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TP53 NM_000546.5:c.1136G>A
NP_000537.3:p.(R379H)
Likely Benign
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TP53 NM_000546.5:c.245C>T
NP_000537.3:p.(P82L)
Likely Benign
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TP53 NM_000546.5:c.105G>T
NP_000537.3:p.(L35F)
Likely Benign
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TP53 NM_000546.6:c.373A>C
NP_000537.3:p.(T125P)
Likely Pathogenic
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TP53 NM_000546.5:c.215C>G
NP_000537.3:p.(P72R)
Benign
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TP53 NM_000546.6:c.722C>A
NP_000537.3:p.(S241Y)
Likely Pathogenic
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TP53 NM_000546.5:c.469G>T
NP_000537.3:p.(V157F)
Likely Pathogenic
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TP53 NM_000546.5:c.764T>A
NP_000537.3:p.(I255N)
Likely Pathogenic
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TP53 NM_000546.6:c.833C>A
NP_000537.3:p.(P278H)
Likely Pathogenic
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