Project HERA
Variant repository
Every variant interpreted by the HERA pipeline, with the criteria and the sources behind each call. Free to read — no account needed.
Browse by gene
Ordered by number of pathogenic calls, then by volume.
PTEN
BRCA2
TP53
ATM
BRCA1
PALB2
MLH1
TET2
NRAS
PTPN11
MSH2
BRAF
KRAS
RUNX1
EGFR
POLE
MSH6
SMARCA4
NF1
STK11
RB1
RET
FH
FLT3
FBXW7
GNAQ
BARD1
APC
CTNNB1
CDKN2A
TSC1
PPM1D
IDH2
NF2
HRAS
ATRX
SMAD4
GNA11
SETD2
ARID1A
IDH1
PIK3CA
POLD1
DICER1
SF3B1
DNMT3A
PIK3R1
ESR1
NOTCH3
FGFR1
ZRSR2
KIT
ERBB2
BCOR
EZH2
CBL
GBA1
SMARCB1
FGFR3
GNAS
PMS2
CHEK2
TSC2
MBD4
PTCH1
NTRK1
RAD51C
ROS1
MLH3
MET
CDK4
RAD51D
CDK12
VHL
CREBBP
FGFR2
EIF1AX
CUX1
MSH3
ATR
FANCD2
BAP1
AR
DDX41
ASXL1
NOTCH2
GALNT12
NOTCH1
RNF43
NTRK2
ETV6
CYP21A2
PDGFRA
MDM2
RAD50
FOXL2
STAG2
FGF3
LRRK2
MPL
FLCN
ABL1
RECQL4
AKT1
PPP2R1A
U2AF1
SMO
CEBPA
NBN
PRKN
FBXO31
FBP1
MAX
MYD88
JAK2
SLC12A3
TERT
PRPF8
BRIP1
RAD51B
AXIN2
EZHIP
MYC
KMT2A
CDH1
BCORL1
KEAP1
MUTYH
CHEK1
FANCL
CDK6
MYCN
PHF6
SETBP1
SDHB
CCND1
FGFR4
SH2B3
GATA2
KLLN
CTNNA1
EPCAM
SDHA
LZTR1
MEN1
BMPR1A
ALK
MYCL
ERBB3
DDR2
NTRK3
SLX4
PPARG
KDR
MAP2K1
HTRA1
B3GALT6
MITF
NFE2L2
H3C2
CDKN2B
SLC2A2
CCNE1
PRKD1
CDC73
MRE11
FANCA
FANCI
RAD54L
MYH7
NTHL1
TARDBP
ANKRD26
WT1
RAF1
MAP2K2
LPL
CREB3L3
AIP
VPS13C
SPG11
SRSF2
HOXB13
POLG
COL4A1
CDK2
ERBB4
STAT3
MDM4
MAPK1
POT1
HNF1A
CCND2
CFTR
RICTOR
PKD1
PSEN1
JAK3
JAK1
GLA
PIK3CB
KMT2B
RAD51
PDCD10
MAP2K4
CACNA1C
DMP1
RPS20
H3-3A
DNAH11
ERCC2
MTOR
EGFL7
MDC1
SOX17
MYOC
TAF1
SDHD
CALR
RAD21
COL4A2
GJB2
Recently interpreted
Newest first across every gene. Pick a gene above to narrow the list.
Variant
Protein change
Classification
MYC
NM_002467.5:c.212_214dup
NP_002458.2:p.(L71dup)
VUS
View →
FANCD2
NM_033084.4:c.3560+2T>A
NP_149075.2:p.?
VUS
View →
ATM
NM_000051.4:c.5574G>A
NP_000042.3:p.(W1858*)
Pathogenic
View →
ATM
NM_000051.4:c.4231del
NP_000042.3:p.(S1411Afs*40)
Pathogenic
View →
ROS1
NM_002944.2:c.6068A>T
NP_002935.2:p.(Y2023F)
VUS
View →
ROS1
NM_002944.2:c.6068A>T
NP_002935.2:p.(Y2023F)
VUS
View →
PTEN
NM_000314.8:c.888T>A
NP_000305.3:p.(C296*)
Likely Pathogenic
View →
POLE
NM_006231.4:c.2284C>T
NP_006222.2:p.(R762W)
VUS
View →
POLE
NM_006231.4:c.2964G>T
NP_006222.2:p.(S988=)
VUS
View →
PTEN
NM_000314.8:c.209T>G
NP_000305.3:p.(L70R)
VUS
View →
PTEN
NM_000314.8:c.46T>G
NP_000305.3:p.(Y16D)
VUS
View →
POLE
NM_006231.4:c.4501G>A
NP_006222.2:p.(G1501R)
VUS
View →
RAD51B
NM_133509.4:c.585_587dup
NP_598193.2:p.(E198dup)
VUS
View →
TSC2
NM_000548.4:c.3796_3797del
NP_000539.2:p.(L1266Afs*55)
Likely Pathogenic
View →
RAD54L
NM_003579.4:c.1093_1169+15dup
NP_003570.2:p.?
VUS
View →
IDH2
NM_002168.3:c.520G>A
NP_002159.2:p.(A174T)
VUS
View →
KRAS
NM_033360.3:c.250A>G
NP_203524.1:p.(I84V)
VUS
View →
IDH2
NM_002168.3:c.413C>A
NP_002159.2:p.(T138N)
VUS
View →
FGF3
NM_005247.2:c.310C>T
NP_005238.1:p.(R104*)
Likely Pathogenic
View →
IDH2
NM_002168.3:c.413C>A
NP_002159.2:p.(T138N)
VUS
View →
IDH2
NM_002168.3:c.413C>A
NP_002159.2:p.(T138N)
VUS
View →
FGFR2
NM_000141.4:c.346G>A
NP_000132.3:p.(E116K)
VUS
View →
RET
NM_020975.5:c.2895G>T
NP_066124.1:p.(K965N)
VUS
View →
NF2
NM_000268.3:c.863C>G
NP_000259.1:p.(S288*)
Likely Pathogenic
View →
PIK3CA
NM_006218.3:c.946C>T
NP_006209.2:p.(P316S)
VUS
View →
MLH1
NM_000249.3:c.676C>T
NP_000240.1:p.(R226*)
Pathogenic
View →
KEAP1
NM_012289.4:c.340G>A
NP_036421.2:p.(G114R)
VUS
View →
FGFR2
NM_000141.4:c.1516G>T
NP_000132.3:p.(D506Y)
VUS
View →
RAD50
NM_005732.3:c.1110A>C
NP_005723.2:p.(L370F)
VUS
View →
MYCL
NM_001033082.2:c.961C>G
NP_001028254.2:p.(R321G)
VUS
View →
NF2
NM_000268.3:c.363+1G>C
NP_000259.1:p.?
VUS
View →
FGFR3
NM_000142.4:c.1172C>T
NP_000133.1:p.(A391V)
Likely Pathogenic
View →
RET
NM_020975.6:c.1783G>A
NP_066124.1:p.(E595K)
VUS
View →
MBD4
NM_003925.3:c.1231_1234del
NP_003916.1:p.(R411Gfs*79)
VUS
View →
ATRX
NM_000489.5:c.4699+2T>C
NP_000480.3:p.?
Likely Pathogenic
View →
IDH2
NM_002168.3:c.413C>A
NP_002159.2:p.(T138N)
VUS
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
ATM
NM_000051.4:c.838A>G
NP_000042.3:p.(I280V)
VUS
View →
MSH6
NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
VUS
View →
MSH6
NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
VUS
View →
MSH6
NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
VUS
View →
MSH6
NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
VUS
View →
ATM
NM_000051.4:c.838A>G
NP_000042.3:p.(I280V)
VUS
View →
CTNNB1
NM_001904.4:c.420T>C
NP_001895.1:p.(I140=)
Benign
View →
ATM
NM_000051.4:c.273dup
NP_000042.3:p.(K92Efs*8)
Pathogenic
View →
ATM
NM_000051.4:c.838A>G
NP_000042.3:p.(I280V)
VUS
View →
ATM
NM_000051.4:c.3080A>G
NP_000042.3:p.(H1027R)
VUS
View →
CDC73
NM_024529.5:c.424-28A>G
NP_078805.3:p.?
Benign
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
ATM
NM_000051.4:c.3080A>G
NP_000042.3:p.(H1027R)
VUS
View →
ATM
NM_000051.4:c.3080A>G
NP_000042.3:p.(H1027R)
VUS
View →
PRKN
NM_004562.2:c.758G>A
NP_004553.2:p.(C253Y)
Likely Pathogenic
View →
ATM
NM_000051.4:c.3080A>G
NP_000042.3:p.(H1027R)
Likely Benign
View →
PRKN
NM_004562.2:c.758G>A
NP_004553.2:p.(C253Y)
Likely Pathogenic
View →
POLD1
NM_002691.4:c.3068-6C>G
NP_002682.2:p.?
VUS
View →
APC
NM_001127510.3:c.295C>T
NP_001120982.1:p.(R99W)
Likely Benign
View →
AXIN2
NM_004655.4:c.1908-23C>T
NP_004646.3:p.?
VUS
View →
STK11
NM_000455.5:c.920+12C>T
NP_000446.1:p.?
VUS
View →
POLE
NM_006231.4:c.5811+16T>C
NP_006222.2:p.?
Benign
View →
POLE
NM_006231.4:c.6766G>A
NP_006222.2:p.(G2256R)
Benign
View →
MSH6
NM_000179.3:c.4001+32_4001+35dup
NP_000170.1:p.?
Likely Benign
View →
BMPR1A
NM_004329.3:c.1299C>T
NP_004320.2:p.(F433=)
Likely Benign
View →
ATM
NM_000051.4:c.103C>A
NP_000042.3:p.(R35=)
Likely Benign
View →
EPCAM
NM_002354.3:c.675G>A
NP_002345.2:p.(L225=)
Likely Benign
View →
MBD4
NM_001276270.2:c.106A>G
NP_001263199.1:p.(K36E)
VUS
View →
CHEK2
NM_007194.4:c.1312G>T
NP_009125.1:p.(D438Y)
VUS
View →
BRCA2
NM_000059.4:c.8039A>G
NP_000050.3:p.(D2680G)
Likely Benign
View →
MBD4
NM_001276270.2:c.1382A>G
NP_001263199.1:p.(N461S)
VUS
View →
BARD1
NM_000465.4:c.1835A>T
NP_000456.2:p.(D612V)
Likely Benign
View →
BRCA1
NM_007294.4:c.19C>T
NP_009225.1:p.(R7C)
VUS
View →
PRKN
NM_004562.2:c.758G>A
NP_004553.2:p.(C253Y)
Likely Pathogenic
View →
PRKN
NM_004562.2:c.758G>A
NP_004553.2:p.(C253Y)
Likely Pathogenic
View →
PTEN
NM_000314.8:c.387_388del
NP_000305.3:p.(R130Nfs*49)
Pathogenic
View →
PTEN
NM_000314.8:c.387_388del
NP_000305.3:p.(R130Nfs*49)
Likely Pathogenic
View →
PTEN
NM_000314.8:c.387_388del
NP_000305.3:p.(R130Nfs*49)
Likely Pathogenic
View →
PTEN
NM_000314.8:c.387_388del
NP_000305.3:p.(R130Nfs*49)
Pathogenic
View →
POLE
NM_006231.4:c.3459+12G>T
NP_006222.2:p.?
VUS
View →
PMS2
NM_000535.7:c.2515C>T
NP_000526.2:p.(H839Y)
VUS
View →
POLE
NM_006231.4:c.6531+19G>T
NP_006222.2:p.?
VUS
View →
PIK3CA
NM_006218.4:c.1911+19G>T
NP_006209.2:p.?
VUS
View →
POLE
NM_006231.4:c.1360-6C>T
NP_006222.2:p.?
Likely Benign
View →
MSH6
NM_000179.3:c.1822A>G
NP_000170.1:p.(I608V)
VUS
View →
TP53
NM_000546.6:c.1154del
NP_000537.3:p.(F385Sfs*37)
VUS
View →
CDH1
NM_004360.5:c.1266A>G
NP_004351.1:p.(Q422=)
VUS
View →
ATM
NM_000051.4:c.7835G>A
NP_000042.3:p.(R2612K)
VUS
View →
POLD1
NM_002691.4:c.187G>A
NP_002682.2:p.(E63K)
VUS
View →
AXIN2
NM_004655.4:c.432T>C
NP_004646.3:p.(I144=)
Benign
View →
POLE
NM_006231.4:c.2561+21G>A
NP_006222.2:p.?
VUS
View →
ATM
NM_000051.4:c.8787-26C>T
NP_000042.3:p.?
Likely Benign
View →
SDHD
NM_003002.4:c.110A>T
NP_002993.1:p.(D37V)
VUS
View →
BRIP1
NM_032043.3:c.254C>T
NP_114432.2:p.(S85L)
VUS
View →
MBD4
NM_001276270.2:c.1024T>C
NP_001263199.1:p.(S342P)
Benign
View →
CDH1
NM_004360.5:c.48+6_48+7delinsTT
NP_004351.1:p.?
VUS
View →
RAD51C
NM_058216.3:c.141C>T
NP_478123.1:p.(S47=)
Likely Benign
View →
BARD1
NM_000465.4:c.1868G>A
NP_000456.2:p.(G623E)
VUS
View →
MBD4
NM_001276270.2:c.335+27T>C
NP_001263199.1:p.?
Benign
View →
APC
NM_001127510.3:c.608A>G
NP_001120982.1:p.(Q203R)
VUS
View →
BARD1
NM_000465.4:c.568G>A
NP_000456.2:p.(D190N)
VUS
View →
MBD4
NM_001276270.2:c.817G>A
NP_001263199.1:p.(A273T)
Benign
View →
MBD4
NM_001276270.2:c.1395C>T
NP_001263199.1:p.(G465=)
Benign
View →