Project HERA
Variant repository
Every variant interpreted by the HERA pipeline, with the criteria and the sources behind each call. Free to read — no account needed.
Browse by gene
Ordered by number of pathogenic calls, then by volume.
PTEN
BRCA2
TP53
ATM
BRCA1
PALB2
MLH1
TET2
NRAS
PTPN11
MSH2
BRAF
KRAS
RUNX1
EGFR
POLE
MSH6
SMARCA4
NF1
STK11
RB1
RET
FH
FLT3
FBXW7
GNAQ
BARD1
APC
CTNNB1
CDKN2A
TSC1
PPM1D
IDH2
NF2
HRAS
ATRX
SMAD4
GNA11
SETD2
ARID1A
IDH1
PIK3CA
POLD1
DICER1
SF3B1
DNMT3A
PIK3R1
ESR1
NOTCH3
FGFR1
ZRSR2
KIT
ERBB2
BCOR
EZH2
CBL
GBA1
SMARCB1
FGFR3
GNAS
PMS2
CHEK2
TSC2
MBD4
PTCH1
NTRK1
RAD51C
ROS1
MLH3
MET
CDK4
RAD51D
CDK12
VHL
CREBBP
FGFR2
EIF1AX
CUX1
MSH3
ATR
FANCD2
BAP1
AR
DDX41
ASXL1
NOTCH2
GALNT12
NOTCH1
RNF43
NTRK2
ETV6
CYP21A2
PDGFRA
MDM2
RAD50
FOXL2
STAG2
FGF3
LRRK2
MPL
FLCN
ABL1
RECQL4
AKT1
PPP2R1A
U2AF1
SMO
CEBPA
NBN
PRKN
FBXO31
FBP1
MAX
MYD88
JAK2
SLC12A3
TERT
PRPF8
BRIP1
RAD51B
AXIN2
EZHIP
MYC
KMT2A
CDH1
BCORL1
KEAP1
MUTYH
CHEK1
FANCL
CDK6
MYCN
PHF6
SETBP1
SDHB
CCND1
FGFR4
SH2B3
GATA2
KLLN
CTNNA1
EPCAM
SDHA
LZTR1
MEN1
BMPR1A
ALK
MYCL
ERBB3
DDR2
NTRK3
SLX4
PPARG
KDR
MAP2K1
HTRA1
B3GALT6
MITF
NFE2L2
H3C2
CDKN2B
SLC2A2
CCNE1
PRKD1
CDC73
MRE11
FANCA
FANCI
RAD54L
MYH7
NTHL1
TARDBP
ANKRD26
WT1
RAF1
MAP2K2
LPL
CREB3L3
AIP
VPS13C
SPG11
SRSF2
HOXB13
POLG
COL4A1
CDK2
ERBB4
STAT3
MDM4
MAPK1
POT1
HNF1A
CCND2
CFTR
RICTOR
PKD1
PSEN1
JAK3
JAK1
GLA
PIK3CB
KMT2B
RAD51
PDCD10
MAP2K4
CACNA1C
DMP1
RPS20
H3-3A
DNAH11
ERCC2
MTOR
EGFL7
MDC1
SOX17
MYOC
TAF1
SDHD
CALR
RAD21
COL4A2
GJB2
Recently interpreted
Newest first across every gene. Pick a gene above to narrow the list.
Variant
Protein change
Classification
MET
NM_001127500.2:c.3082G>C
NP_001120972.1:p.(D1028H)
VUS
View →
NTRK1
NM_002529.3:c.655G>A
NP_002520.2:p.(G219R)
VUS
View →
RAD51B
NM_133509.4:c.82C>G
NP_598193.2:p.(Q28E)
VUS
View →
PTEN
NM_000314.8:c.197_203del
NP_000305.3:p.(K66Tfs*31)
Likely Pathogenic
View →
DICER1
NM_177438.3:c.735-23A>G
NP_803187.1:p.?
Likely Benign
View →
MSH6
NM_000179.3:c.4002-16_4002-10del
NP_000170.1:p.?
VUS
View →
MLH1
NM_000249.4:c.1732-2A>G
NP_000240.1:p.?
Pathogenic
View →
FGFR3
NM_000142.4:c.1959C>T
NP_000133.1:p.(N653=)
VUS
View →
BRCA1
NM_007294.4:c.3260G>C
NP_009225.1:p.(G1087A)
VUS
View →
STK11
NM_000455.4:c.369G>A
NP_000446.1:p.(Q123=)
Benign
View →
HRAS
NM_005343.4:c.7G>A
NP_005334.1:p.(E3K)
VUS
View →
CDK4
NM_000075.4:c.122A>G
NP_000066.1:p.(N41S)
VUS
View →
TSC2
NM_000548.4:c.5335del
NP_000539.2:p.(Q1779Rfs*47)
VUS
View →
FLT3
NM_004119.2:c.2515G>A
NP_004110.2:p.(D839N)
VUS
View →
CCND1
NM_053056.3:c.844G>A
NP_444284.1:p.(D282N)
VUS
View →
MYC
NM_002467.6:c.221C>G
NP_002458.2:p.(P74R)
VUS
View →
NF2
NM_000268.3:c.778G>T
NP_000259.1:p.(E260*)
VUS
View →
KEAP1
NM_012289.4:c.1639G>A
NP_036421.2:p.(V547I)
VUS
View →
PIK3R1
NM_181523.2:c.1350_1374del
NP_852664.1:p.(H450Qfs*22)
Likely Pathogenic
View →
PIK3CA
NM_006218.3:c.277C>T
NP_006209.2:p.(R93W)
VUS
View →
MYCN
NM_005378.5:c.868A>G
NP_005369.2:p.(N290D)
VUS
View →
MSH6
NM_000179.2:c.3926C>A
NP_000170.1:p.(P1309Q)
VUS
View →
ATM
NM_000051.3:c.1348G>T
NP_000042.3:p.(E450*)
Pathogenic
View →
FGFR2
NM_000141.4:c.2383G>A
NP_000132.3:p.(D795N)
VUS
View →
MSH6
NM_000179.2:c.2975A>G
NP_000170.1:p.(E992G)
VUS
View →
CDK4
NM_000075.3:c.803G>A
NP_000066.1:p.(G268E)
VUS
View →
PTCH1
NM_000264.5:c.2215_2216delinsTT
NP_000255.2:p.(H739F)
VUS
View →
ARID1A
NM_006015.5:c.2297A>T
NP_006006.3:p.(Q766L)
VUS
View →
NOTCH3
NM_000435.2:c.3278G>T
NP_000426.2:p.(C1093F)
Likely Pathogenic
View →
PTEN
NM_000314.6:c.95T>G
NP_000305.3:p.(I32S)
VUS
View →
DICER1
NM_177438.2:c.2536A>G
NP_803187.1:p.(I846V)
VUS
View →
MYCN
NM_005378.5:c.368G>T
NP_005369.2:p.(R123L)
VUS
View →
TERT
NM_198253.2:c.1812A>G
NP_937983.2:p.(A604=)
VUS
View →
PPM1D
NM_003620.3:c.1570del
NP_003611.1:p.(Q524Kfs*15)
VUS
View →
RAD21
NM_006265.2:c.165A>G
NP_006256.1:p.(T55=)
Likely Benign
View →
PRPF8
NM_006445.3:c.3081A>T
NP_006436.3:p.(S1027=)
VUS
View →
TET2
NM_001127208.2:c.2193A>G
NP_001120680.1:p.(Q731=)
VUS
View →
SETBP1
NM_015559.2:c.575A>G
NP_056374.2:p.(H192R)
VUS
View →
PPM1D
NM_003620.3:c.1260+4T>C
NP_003611.1:p.?
VUS
View →
KMT2A
NM_005933.3:c.10244C>T
NP_005924.2:p.(P3415L)
VUS
View →
IDH2
NM_002168.2:c.374-10G>A
NP_002159.2:p.?
VUS
View →
BCORL1
NM_021946.4:c.1953C>T
NP_068765.3:p.(H651=)
VUS
View →
PHF6
NM_001015877.1:c.859G>C
NP_001015877.1:p.(G287R)
VUS
View →
KRAS
NM_033360.2:c.57G>T
NP_203524.1:p.(L19F)
VUS
View →
TET2
NM_001127208.2:c.2119G>A
NP_001120680.1:p.(A707T)
VUS
View →
NF2
NM_000268.3:c.958C>T
NP_000259.1:p.(Q320*)
VUS
View →
CDKN2A
NM_001195132.1:c.44_46dup
NP_001182061.1:p.(W15_L16insR)
VUS
View →
MET
NM_001127500.3:c.1063G>A
NP_001120972.1:p.(E355K)
VUS
View →
RET
NM_020975.5:c.2486G>A
NP_066124.1:p.(S829N)
VUS
View →
CCND1
NM_053056.3:c.839_841del
NP_444284.1:p.(E280del)
Likely Benign
View →
RAD51B
NM_133509.4:c.171_173dup
NP_598193.2:p.(S57dup)
Likely Benign
View →
CREBBP
NM_004380.2:c.7299C>A
NP_004371.2:p.(D2433E)
VUS
View →
CALR
NM_004343.3:c.1066C>G
NP_004334.1:p.(Q356E)
VUS
View →
CALR
NM_004343.3:c.1066C>G
NP_004334.1:p.(Q356E)
—
View →
GALNT12
NM_024642.5:c.460C>T
NP_078918.3:p.(R154W)
VUS
View →
BCOR
NM_017745.5:c.2265C>A
NP_060215.4:p.(Y755*)
Likely Pathogenic
View →
POLD1
NM_002691.4:c.2959del
NP_002682.2:p.(D987Tfs*58)
Likely Pathogenic
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
MSH6
NM_000179.3:c.2731C>T
NP_000170.1:p.(R911*)
Pathogenic
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
PRPF8
NM_006445.3:c.2013A>G
NP_006436.3:p.(T671=)
VUS
View →
BCOR
NM_017745.5:c.3870_3871insC
NP_060215.4:p.(K1291Qfs*84)
Likely Pathogenic
View →
STAG2
NM_001042749.1:c.2431G>T
NP_001036214.1:p.(E811*)
VUS
View →
RUNX1
NM_001754.4:c.707dup
NP_001745.2:p.(M236Ifs*25)
Pathogenic
View →
RUNX1
NM_001754.4:c.560C>T
NP_001745.2:p.(A187V)
VUS
View →
NF1
NM_001042492.2:c.2544G>A
NP_001035957.1:p.(G848=)
Benign
View →
NF1
NM_001042492.2:c.2022C>T
NP_001035957.1:p.(S674=)
Benign
View →
CUX1
NM_001202543.1:c.2598_2606dup
NP_001189472.1:p.(S868_G870dup)
Benign
View →
KMT2A
NM_005933.3:c.2040G>T
NP_005924.2:p.(S680=)
VUS
View →
DDX41
NM_016222.2:c.1479C>T
NP_057306.2:p.(S493=)
Likely Benign
View →
TERT
NM_198253.2:c.2283C>T
NP_937983.2:p.(S761=)
VUS
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
MSH2
NM_000251.3:c.2005+1G>A
NP_000242.1:p.?
Likely Pathogenic
View →
MLH1
NM_000249.4:c.1039-6dup
NP_000240.1:p.?
Benign
View →
MLH1
NM_000249.4:c.1039-6dup
NP_000240.1:p.?
VUS
View →
MSH2
NM_000251.3:c.1255C>T
NP_000242.1:p.(Q419*)
Pathogenic
View →
MSH6
NM_000179.3:c.1403G>A
NP_000170.1:p.(R468H)
Likely Benign
View →
MLH1
NM_000249.4:c.1558+4C>T
NP_000240.1:p.?
VUS
View →
MLH1
NM_000249.4:c.1039-6dup
NP_000240.1:p.?
VUS
View →
MET
NM_001127500.2:c.737C>T
NP_001120972.1:p.(P246L)
VUS
View →
MSH3
NM_002439.5:c.2041C>T
NP_002430.3:p.(P681S)
VUS
View →
RAD51C
NM_058216.3:c.187A>T
NP_478123.1:p.(I63F)
VUS
View →
POLE
NM_006231.4:c.286-8C>G
NP_006222.2:p.?
VUS
View →
GALNT12
NM_024642.5:c.123T>G
NP_078918.3:p.(R41=)
VUS
View →
BAP1
NM_004656.4:c.126T>C
NP_004647.1:p.(P42=)
VUS
View →
POLE
NM_006231.4:c.331-30G>A
NP_006222.2:p.?
VUS
View →
POLE
NM_006231.4:c.3332G>A
NP_006222.2:p.(R1111Q)
VUS
View →
MUTYH
NM_001128425.2:c.1465G>A
NP_001121897.1:p.(A489T)
VUS
View →
GBA1
NM_000157.4:c.1093G>A
NP_000148.2:p.(E365K)
Benign
View →
IDH2
NM_002168.3:c.413C>A
NP_002159.2:p.(T138N)
VUS
View →
IDH2
NM_002168.3:c.413C>A
NP_002159.2:p.(T138N)
VUS
View →
IDH2
NM_002168.3:c.413C>A
NP_002159.2:p.(T138N)
VUS
View →
ERBB2
NM_004448.3:c.2584A>G
NP_004439.2:p.(T862A)
Likely Pathogenic
View →
NF2
NM_000268.3:c.1249A>T
NP_000259.1:p.(I417F)
VUS
View →
FOXL2
NM_023067.4:c.386C>T
NP_075555.1:p.(T129M)
VUS
View →
MLH3
NM_001040108.2:c.3455G>A
NP_001035197.1:p.(R1152H)
VUS
View →
BRCA2
NM_000059.4:c.4183G>T
NP_000050.3:p.(A1395S)
Likely Benign
View →
TSC1
NM_000368.5:c.2865C>T
NP_000359.1:p.(T955=)
Benign
View →
FLCN
NM_144997.7:c.1177-5_1177-3del
NP_659434.2:p.?
Pathogenic
View →