Project HERA
Variant repository
Every variant interpreted by the HERA pipeline, with the criteria and the sources behind each call. Free to read — no account needed.
Browse by gene
Ordered by number of pathogenic calls, then by volume.
PTEN
BRCA2
TP53
ATM
BRCA1
PALB2
MLH1
TET2
NRAS
PTPN11
MSH2
BRAF
KRAS
RUNX1
EGFR
POLE
MSH6
SMARCA4
NF1
STK11
RB1
RET
FH
FLT3
FBXW7
GNAQ
BARD1
APC
CTNNB1
CDKN2A
TSC1
PPM1D
IDH2
NF2
HRAS
ATRX
SMAD4
GNA11
SETD2
ARID1A
IDH1
PIK3CA
POLD1
DICER1
SF3B1
DNMT3A
PIK3R1
ESR1
NOTCH3
FGFR1
ZRSR2
KIT
ERBB2
BCOR
EZH2
CBL
GBA1
SMARCB1
FGFR3
GNAS
PMS2
CHEK2
TSC2
MBD4
PTCH1
NTRK1
RAD51C
ROS1
MLH3
MET
CDK4
RAD51D
CDK12
VHL
CREBBP
FGFR2
EIF1AX
CUX1
MSH3
ATR
FANCD2
BAP1
AR
DDX41
ASXL1
NOTCH2
GALNT12
NOTCH1
RNF43
NTRK2
ETV6
CYP21A2
PDGFRA
MDM2
RAD50
FOXL2
STAG2
FGF3
LRRK2
MPL
FLCN
ABL1
RECQL4
AKT1
PPP2R1A
U2AF1
SMO
CEBPA
NBN
PRKN
FBXO31
FBP1
MAX
MYD88
JAK2
SLC12A3
TERT
PRPF8
BRIP1
RAD51B
AXIN2
EZHIP
MYC
KMT2A
CDH1
BCORL1
KEAP1
MUTYH
CHEK1
FANCL
CDK6
MYCN
PHF6
SETBP1
SDHB
CCND1
FGFR4
SH2B3
GATA2
KLLN
CTNNA1
EPCAM
SDHA
LZTR1
MEN1
BMPR1A
ALK
MYCL
ERBB3
DDR2
NTRK3
SLX4
PPARG
KDR
MAP2K1
HTRA1
B3GALT6
MITF
NFE2L2
H3C2
CDKN2B
SLC2A2
CCNE1
PRKD1
CDC73
MRE11
FANCA
FANCI
RAD54L
MYH7
NTHL1
TARDBP
ANKRD26
WT1
RAF1
MAP2K2
LPL
CREB3L3
AIP
VPS13C
SPG11
SRSF2
HOXB13
POLG
COL4A1
CDK2
ERBB4
STAT3
MDM4
MAPK1
POT1
HNF1A
CCND2
CFTR
RICTOR
PKD1
PSEN1
JAK3
JAK1
GLA
PIK3CB
KMT2B
RAD51
PDCD10
MAP2K4
CACNA1C
DMP1
RPS20
H3-3A
DNAH11
ERCC2
MTOR
EGFL7
MDC1
SOX17
MYOC
TAF1
SDHD
CALR
RAD21
COL4A2
GJB2
Recently interpreted
Newest first across every gene. Pick a gene above to narrow the list.
Variant
Protein change
Classification
TP53
NM_000546.6:c.1118A>G
NP_000537.3:p.(K373R)
Likely Benign
View →
TP53
NM_000546.6:c.1118A>G
NP_000537.3:p.(K373R)
In progress — classification not generated yet.
View →
TP53
NM_000546.6:c.599_600del
NP_000537.3:p.(N200Ifs*8)
In progress — classification not generated yet.
View →
TP53
NM_000546.6:c.797G>T
NP_000537.3:p.(G266V)
VUS
View →
TSC2
NM_000548.5:c.1292C>T
NP_000539.2:p.(A431V)
VUS
View →
NF1
NM_001042492.3:c.6737del
NP_001035957.1:p.(P2246Qfs*19)
Likely Pathogenic
View →
TARDBP
NM_007375.4:c.883G>A
NP_031401.1:p.(G295S)
VUS
View →
TARDBP
NM_007375.4:c.881G>T
NP_031401.1:p.(G294V)
VUS
View →
MSH6
NM_000179.3:c.3674C>T
NP_000170.1:p.(T1225M)
VUS
View →
RB1
NM_000321.3:c.*1G>C
NP_000312.2:p.?
VUS
View →
GJB2
NM_004004.6:c.445G>A
NP_003995.2:p.(A149T)
VUS
View →
RB1
NM_000321.3:c.1390-17T>A
NP_000312.2:p.?
VUS
View →
TP53
NM_000546.6:c.797G>T
NP_000537.3:p.(G266V)
VUS
View →
POLE
NM_006231.4:c.4275C>T
NP_006222.2:p.(G1425=)
VUS
View →
TP53
NM_000546.6:c.1001G>T
NP_000537.3:p.(G334V)
VUS
View →
DICER1
NM_177438.3:c.4014G>A
NP_803187.1:p.(A1338=)
Benign
View →
RET
NM_020975.6:c.2073T>C
NP_066124.1:p.(G691=)
VUS
View →
ATM
NM_000051.4:c.4324T>C
NP_000042.3:p.(Y1442H)
VUS
View →
TSC2
NM_000548.5:c.2476C>A
NP_000539.2:p.(L826M)
Likely Benign
View →
VHL
NM_000551.4:c.541G>A
NP_000542.1:p.(V181I)
VUS
View →
—
VUS
View →
TP53
NM_000546.6:c.266_267del
NP_000537.3:p.(P89Lfs*59)
Likely Pathogenic
View →
PTEN
NM_000314.8:c.395G>T
NP_000305.3:p.(G132V)
VUS
View →
PTEN
NM_000314.8:c.129_155del
NP_000305.3:p.(E43_D51del)
VUS
View →
PTEN
NM_000314.8:c.63C>T
NP_000305.3:p.(F21=)
VUS
View →
PMS2
NM_000535.7:c.1169C>G
NP_000526.2:p.(A390G)
VUS
View →
MLH1
NM_000249.4:c.2044_2045del
NP_000240.1:p.(M682Vfs*11)
VUS
View →
MLH1
NM_000249.4:c.549T>A
NP_000240.1:p.(Y183*)
VUS
View →
PTEN
NM_000314.8:c.1027-2A>C
NP_000305.3:p.?
Pathogenic
View →
PTEN
NM_000314.8:c.700_701del
NP_000305.3:p.(R234Gfs*8)
Likely Pathogenic
View →
BRCA2
NM_000059.4:c.6546_6574del
NP_000050.3:p.(K2182Nfs*5)
—
View →
BRCA2
NM_000059.4:c.7317A>G
NP_000050.3:p.(G2439=)
Likely Benign
View →
BRCA2
NM_000059.4:c.2164A>T
NP_000050.3:p.(K722*)
VUS
View →
TP53
NM_000546.6:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
View →
FGFR4
NM_213647.2:c.770C>T
NP_998812.1:p.(A257V)
VUS
View →
CDKN2A
NM_001195132.1:c.341C>T
NP_001182061.1:p.(P114L)
Pathogenic
View →
NRAS
NM_002524.5:c.182A>T
NP_002515.1:p.(Q61L)
VUS
View →
MYCN
NM_005378.5:c.926G>T
NP_005369.2:p.(G309V)
VUS
View →
CDKN2A
NM_000077.4:c.76G>C
NP_000068.1:p.(E26Q)
VUS
View →
NF1
NM_001042492.2:c.*4T>C
NP_001035957.1:p.?
Benign
View →
SETBP1
NM_015559.2:c.1150A>G
NP_056374.2:p.(R384G)
VUS
View →
PRPF8
NM_006445.3:c.4639-17T>G
NP_006436.3:p.?
Benign
View →
NF1
NM_001042492.2:c.4836-2A>G
NP_001035957.1:p.?
Pathogenic
View →
ETV6
NM_001987.4:c.1204T>G
NP_001978.1:p.(Y402D)
VUS
View →
ASXL1
NM_015338.5:c.2148dup
NP_056153.2:p.(R717*)
VUS
View →
ZRSR2
NM_005089.3:c.983_984insGAA
NP_005080.1:p.(F328delinsLN)
VUS
View →
ETV6
NM_001987.4:c.642G>A
NP_001978.1:p.(P214=)
Benign
View →
RAD51C
NM_058216.3:c.905-19T>C
NP_478123.1:p.?
VUS
View →
POLD1
NM_002691.4:c.1275C>T
NP_002682.2:p.(A425=)
Likely Benign
View →
SDHB
NM_003000.3:c.158G>A
NP_002991.2:p.(G53E)
Benign
View →
MSH6
NM_000179.3:c.2463A>C
NP_000170.1:p.(L821=)
Likely Benign
View →
TSC1
NM_000368.5:c.163C>T
NP_000359.1:p.(Q55*)
Likely Pathogenic
View →
AXIN2
NM_004655.4:c.2013_2024del
NP_004646.3:p.(T672_R675del)
Benign
View →
CTNNA1
NM_001903.5:c.347G>A
NP_001894.2:p.(C116Y)
VUS
View →
APC
NM_001127510.3:c.3479C>A
NP_001120982.1:p.(T1160K)
Likely Benign
View →
POLD1
NM_002691.4:c.653G>A
NP_002682.2:p.(R218H)
Likely Benign
View →
FANCD2
NM_033084.4:c.2255T>C
NP_149075.2:p.(I752T)
VUS
View →
NTHL1
NM_002528.7:c.31C>T
NP_002519.2:p.(R11W)
VUS
View →
NOTCH1
NM_017617.5:c.5885G>A
NP_060087.3:p.(R1962H)
VUS
View →
FGFR1
NM_001174067.1:c.1746C>A
NP_001167538.1:p.(C582*)
Likely Pathogenic
View →
PTEN
NM_000314.6:c.674_675dup
NP_000305.3:p.(S226Ifs*31)
Likely Pathogenic
View →
CDKN2A
NM_000077.4:c.221A>T
NP_000068.1:p.(D74V)
VUS
View →
NOTCH3
NM_000435.2:c.3192A>T
NP_000426.2:p.(E1064D)
VUS
View →
POLE
NM_006231.4:c.941C>A
NP_006222.2:p.(S314*)
Likely Pathogenic
View →
KRAS
NM_033360.4:c.292G>T
NP_203524.1:p.(E98*)
VUS
View →
POLE
NM_006231.4:c.4519_4520del
NP_006222.2:p.(Q1507Afs*37)
Likely Pathogenic
View →
CHEK1
NM_001274.5:c.484C>T
NP_001265.2:p.(R162C)
VUS
View →
MSH2
NM_000251.3:c.712del
NP_000242.1:p.(Y238Ifs*8)
VUS
View →
PTEN
NM_000314.8:c.775_781del
NP_000305.3:p.(H259Rfs*5)
Likely Pathogenic
View →
CTNNB1
NM_001904.4:c.134C>A
NP_001895.1:p.(S45Y)
VUS
View →
NOTCH2
NM_024408.3:c.5625del
NP_077719.2:p.(T1876Lfs*54)
Likely Pathogenic
View →
MLH1
NM_000249.4:c.1732-2A>G
NP_000240.1:p.?
Pathogenic
View →
SETD2
NM_014159.6:c.4260del
NP_054878.5:p.(E1420Dfs*12)
Likely Pathogenic
View →
COL4A2
NM_001846.4:c.4183C>T
NP_001837.2:p.(Q1395*)
VUS
View →
CDKN2A
NM_000077.4:c.307_308insT
NP_000068.1:p.(R103Lfs*17)
Likely Pathogenic
View →
BRIP1
NM_032043.3:c.2593C>T
NP_114432.2:p.(R865W)
VUS
View →
PIK3R1
NM_181523.2:c.1126G>A
NP_852664.1:p.(G376R)
VUS
View →
SF3B1
NM_012433.3:c.2469G>A
NP_036565.2:p.(M823I)
VUS
View →
FBXW7
NM_033632.3:c.608C>T
NP_361014.1:p.(S203L)
VUS
View →
FBXW7
NM_033632.3:c.1436G>A
NP_361014.1:p.(R479Q)
Likely Pathogenic
View →
FGFR2
NM_000141.4:c.819C>G
NP_000132.3:p.(D273E)
VUS
View →
APC
NM_001127510.3:c.8511T>C
NP_001120982.1:p.(S2837=)
Likely Benign
View →
BRCA2
NM_000059.4:c.2133C>T
NP_000050.3:p.(C711=)
Likely Benign
View →
ATM
NM_000051.4:c.4394T>C
NP_000042.3:p.(L1465P)
VUS
View →
SDHB
NM_003000.3:c.178A>G
NP_002991.2:p.(T60A)
VUS
View →
POLD1
NM_002691.4:c.1562G>A
NP_002682.2:p.(R521Q)
VUS
View →
CCNE1
NM_001238.4:c.617A>G
NP_001229.1:p.(Y206C)
VUS
View →
BRCA1
NM_007294.4:c.3260G>C
NP_009225.1:p.(G1087A)
Likely Benign
View →
BRCA1
NM_007294.4:c.3260G>C
NP_009225.1:p.(G1087A)
VUS
View →
HRAS
NM_005343.4:c.173C>T
NP_005334.1:p.(T58I)
Likely Pathogenic
View →
HRAS
NM_001130442.2:c.34G>A
NP_001123914.1:p.(G12S)
Pathogenic
View →
TP53
NM_000546.6:c.266_267del
NP_000537.3:p.(P89Lfs*59)
Likely Pathogenic
View →
ESR1
NM_001122740.1:c.1163T>A
NP_001116212.1:p.(M388K)
Likely Pathogenic
View →
TP53
NM_000546.6:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
View →
TP53
NM_000546.6:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
View →
EZHIP
NM_203407.3:c.1379C>G
NP_981952.1:p.(S460C)
VUS
View →
KRAS
NM_033360.3:c.35G>T
NP_203524.1:p.(G12V)
VUS
View →
ARID1A
NM_006015.5:c.1217_1229dup
NP_006006.3:p.(P411Tfs*216)
Likely Pathogenic
View →
RET
NM_020975.5:c.1837C>A
NP_066124.1:p.(P613T)
VUS
View →
NF1
NM_001042492.2:c.2190C>G
NP_001035957.1:p.(N730K)
VUS
View →