Project HERA
Variant repository
Browse completed HERA interpretations, including applied criteria and available source records. No account is required to read reports.
Browse by gene
Ordered by number of pathogenic calls, then by volume.
PTEN
TP53
BRCA2
ATM
BRCA1
PALB2
EGFR
MLH1
KRAS
POLE
BRAF
TET2
PTPN11
NRAS
IDH1
MSH6
MSH2
RUNX1
KIT
FGFR3
NF1
CTNNB1
DNMT3A
RET
IDH2
SMARCA4
FLT3
FBXW7
CFTR
GNAQ
APC
BARD1
STK11
CDKN2A
RB1
ESR1
HRAS
FH
SMAD4
GNA11
GNAS
PIK3CA
SF3B1
ERBB2
TSC1
PPM1D
FGFR2
NF2
CBL
ALK
ATRX
EZH2
GBA1
SETD2
ARID1A
TTR
POLD1
CHEK2
DICER1
MUTYH
RAD51C
RAD51D
PIK3R1
VHL
NOTCH3
FGFR1
ZRSR2
ASXL1
BCOR
MPL
MAP2K1
SMARCB1
U2AF1
AKT1
NBN
JAK2
HEXA
PKP2
PMS2
TSC2
MBD4
PTCH1
MSH3
NTRK1
MLH3
MET
ROS1
SDHB
CDK4
BAP1
CDK12
CREBBP
EIF1AX
PHF6
CUX1
GALNT12
NOTCH1
ATR
FANCD2
AR
DDX41
NOTCH2
RNF43
NTRK2
ETV6
CYP21A2
PDGFRA
MDM2
ERBB3
RAD50
FOXL2
STAG2
FGF3
NTHL1
ABL1
LRRK2
MYH7
HBB
LDLR
FLCN
RECQL4
STAT3
MYD88
PPP2R1A
SMO
CEBPA
PRKN
MYBPC3
RYR1
KCNQ1
RAC1
FBXO31
FBP1
MAX
SLC12A3
DPYD
MEFV
NOD2
CSF3R
ATP7B
BTD
CXCR4
ACADM
MED12
ACVR1
PRNP
PRSS1
ASPA
ELP1
LMNA
BLM
DHCR7
KCNJ11
TERT
PRPF8
BRIP1
AXIN2
RAD51B
EZHIP
MYC
KMT2A
CDH1
BCORL1
KEAP1
CHEK1
FANCL
CDK6
MYCN
SETBP1
KLLN
CTNNA1
BMPR1A
CCND1
FGFR4
SH2B3
GATA2
MEN1
GJB2
EPCAM
SDHA
LZTR1
MYCL
DDR2
NTRK3
SLX4
PPARG
KDR
CALR
HFE
SRSF2
HOXB13
HTRA1
B3GALT6
MITF
NFE2L2
H3C2
CDKN2B
SLC2A2
HNF1A
CCNE1
PRKD1
GLA
CDC73
MRE11
FANCA
H3-3A
FANCI
RAD54L
SDHD
TARDBP
SERPINA1
MTHFR
G6PD
APOL1
ANKRD26
WT1
RAF1
MAP2K2
LPL
CREB3L3
AIP
VPS13C
SPG11
POLG
COL4A1
CDK2
ERBB4
MDM4
MAPK1
POT1
CCND2
RICTOR
PKD1
PSEN1
JAK3
JAK1
PIK3CB
KMT2B
RAD51
PDCD10
MAP2K4
CACNA1C
DMP1
RPS20
DNAH11
ERCC2
MTOR
EGFL7
MDC1
SOX17
MYOC
TAF1
RAD21
COL4A2
DLST
PTPN4
NPM1
F5
APOB
APOE
CYP2C19
SLCO1B1
CYP2C9
PAH
TPMT
FANCC
GALT
CYP3A5
SLC26A4
SPINK1
Recently interpreted
Newest first across every gene. Pick a gene above to narrow the list.
Variant
Protein change
Classification
PIK3R1
NM_181523.2:c.1126G>A
NP_852664.1:p.(G376R)
VUS
View →
SF3B1
NM_012433.3:c.2469G>A
NP_036565.2:p.(M823I)
VUS
View →
FBXW7
NM_033632.3:c.608C>T
NP_361014.1:p.(S203L)
VUS
View →
FBXW7
NM_033632.3:c.1436G>A
NP_361014.1:p.(R479Q)
Likely Pathogenic
View →
FGFR2
NM_000141.4:c.819C>G
NP_000132.3:p.(D273E)
VUS
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APC
NM_001127510.3:c.8511T>C
NP_001120982.1:p.(S2837=)
Likely Benign
View →
BRCA2
NM_000059.4:c.2133C>T
NP_000050.3:p.(C711=)
Likely Benign
View →
ATM
NM_000051.4:c.4394T>C
NP_000042.3:p.(L1465P)
VUS
View →
SDHB
NM_003000.3:c.178A>G
NP_002991.2:p.(T60A)
VUS
View →
POLD1
NM_002691.4:c.1562G>A
NP_002682.2:p.(R521Q)
VUS
View →
CCNE1
NM_001238.4:c.617A>G
NP_001229.1:p.(Y206C)
VUS
View →
BRCA1
NM_007294.4:c.3260G>C
NP_009225.1:p.(G1087A)
Likely Benign
View →
BRCA1
NM_007294.4:c.3260G>C
NP_009225.1:p.(G1087A)
VUS
View →
HRAS
NM_005343.4:c.173C>T
NP_005334.1:p.(T58I)
Likely Pathogenic
View →
HRAS
NM_001130442.2:c.34G>A
NP_001123914.1:p.(G12S)
Pathogenic
View →
TP53
NM_000546.6:c.266_267del
NP_000537.3:p.(P89Lfs*59)
Likely Pathogenic
View →
ESR1
NM_001122740.1:c.1163T>A
NP_001116212.1:p.(M388K)
Likely Pathogenic
View →
TP53
NM_000546.6:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
View →
TP53
NM_000546.6:c.1066G>C
NP_000537.3:p.(G356R)
Likely Benign
View →
EZHIP
NM_203407.3:c.1379C>G
NP_981952.1:p.(S460C)
VUS
View →
KRAS
NM_033360.3:c.35G>T
NP_203524.1:p.(G12V)
VUS
View →
ARID1A
NM_006015.5:c.1217_1229dup
NP_006006.3:p.(P411Tfs*216)
Likely Pathogenic
View →
RET
NM_020975.5:c.1837C>A
NP_066124.1:p.(P613T)
VUS
View →
NF1
NM_001042492.2:c.2190C>G
NP_001035957.1:p.(N730K)
VUS
View →
MET
NM_001127500.2:c.3082G>C
NP_001120972.1:p.(D1028H)
VUS
View →
NTRK1
NM_002529.3:c.655G>A
NP_002520.2:p.(G219R)
VUS
View →
RAD51B
NM_133509.4:c.82C>G
NP_598193.2:p.(Q28E)
VUS
View →
PTEN
NM_000314.8:c.197_203del
NP_000305.3:p.(K66Tfs*31)
Likely Pathogenic
View →
DICER1
NM_177438.3:c.735-23A>G
NP_803187.1:p.?
Likely Benign
View →
MSH6
NM_000179.3:c.4002-16_4002-10del
NP_000170.1:p.?
VUS
View →
MLH1
NM_000249.4:c.1732-2A>G
NP_000240.1:p.?
Pathogenic
View →
FGFR3
NM_000142.4:c.1959C>T
NP_000133.1:p.(N653=)
VUS
View →
BRCA1
NM_007294.4:c.3260G>C
NP_009225.1:p.(G1087A)
VUS
View →
STK11
NM_000455.4:c.369G>A
NP_000446.1:p.(Q123=)
Benign
View →
HRAS
NM_005343.4:c.7G>A
NP_005334.1:p.(E3K)
VUS
View →
CDK4
NM_000075.4:c.122A>G
NP_000066.1:p.(N41S)
VUS
View →
TSC2
NM_000548.4:c.5335del
NP_000539.2:p.(Q1779Rfs*47)
VUS
View →
FLT3
NM_004119.2:c.2515G>A
NP_004110.2:p.(D839N)
VUS
View →
CCND1
NM_053056.3:c.844G>A
NP_444284.1:p.(D282N)
VUS
View →
MYC
NM_002467.6:c.221C>G
NP_002458.2:p.(P74R)
VUS
View →
NF2
NM_000268.3:c.778G>T
NP_000259.1:p.(E260*)
VUS
View →
KEAP1
NM_012289.4:c.1639G>A
NP_036421.2:p.(V547I)
VUS
View →
PIK3R1
NM_181523.2:c.1350_1374del
NP_852664.1:p.(H450Qfs*22)
Likely Pathogenic
View →
PIK3CA
NM_006218.3:c.277C>T
NP_006209.2:p.(R93W)
VUS
View →
MYCN
NM_005378.5:c.868A>G
NP_005369.2:p.(N290D)
VUS
View →
MSH6
NM_000179.2:c.3926C>A
NP_000170.1:p.(P1309Q)
VUS
View →
ATM
NM_000051.3:c.1348G>T
NP_000042.3:p.(E450*)
Pathogenic
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FGFR2
NM_000141.4:c.2383G>A
NP_000132.3:p.(D795N)
VUS
View →
MSH6
NM_000179.2:c.2975A>G
NP_000170.1:p.(E992G)
VUS
View →
CDK4
NM_000075.3:c.803G>A
NP_000066.1:p.(G268E)
VUS
View →
PTCH1
NM_000264.5:c.2215_2216delinsTT
NP_000255.2:p.(H739F)
VUS
View →
ARID1A
NM_006015.5:c.2297A>T
NP_006006.3:p.(Q766L)
VUS
View →
NOTCH3
NM_000435.2:c.3278G>T
NP_000426.2:p.(C1093F)
Likely Pathogenic
View →
PTEN
NM_000314.6:c.95T>G
NP_000305.3:p.(I32S)
VUS
View →
DICER1
NM_177438.2:c.2536A>G
NP_803187.1:p.(I846V)
VUS
View →
MYCN
NM_005378.5:c.368G>T
NP_005369.2:p.(R123L)
VUS
View →
TERT
NM_198253.2:c.1812A>G
NP_937983.2:p.(A604=)
VUS
View →
PPM1D
NM_003620.3:c.1570del
NP_003611.1:p.(Q524Kfs*15)
VUS
View →
RAD21
NM_006265.2:c.165A>G
NP_006256.1:p.(T55=)
Likely Benign
View →
PRPF8
NM_006445.3:c.3081A>T
NP_006436.3:p.(S1027=)
VUS
View →
TET2
NM_001127208.2:c.2193A>G
NP_001120680.1:p.(Q731=)
VUS
View →
SETBP1
NM_015559.2:c.575A>G
NP_056374.2:p.(H192R)
VUS
View →
PPM1D
NM_003620.3:c.1260+4T>C
NP_003611.1:p.?
VUS
View →
KMT2A
NM_005933.3:c.10244C>T
NP_005924.2:p.(P3415L)
VUS
View →
IDH2
NM_002168.2:c.374-10G>A
NP_002159.2:p.?
VUS
View →
BCORL1
NM_021946.4:c.1953C>T
NP_068765.3:p.(H651=)
VUS
View →
PHF6
NM_001015877.1:c.859G>C
NP_001015877.1:p.(G287R)
VUS
View →
KRAS
NM_033360.2:c.57G>T
NP_203524.1:p.(L19F)
VUS
View →
TET2
NM_001127208.2:c.2119G>A
NP_001120680.1:p.(A707T)
VUS
View →
NF2
NM_000268.3:c.958C>T
NP_000259.1:p.(Q320*)
VUS
View →
CDKN2A
NM_001195132.1:c.44_46dup
NP_001182061.1:p.(W15_L16insR)
VUS
View →
MET
NM_001127500.3:c.1063G>A
NP_001120972.1:p.(E355K)
VUS
View →
RET
NM_020975.5:c.2486G>A
NP_066124.1:p.(S829N)
VUS
View →
CCND1
NM_053056.3:c.839_841del
NP_444284.1:p.(E280del)
Likely Benign
View →
RAD51B
NM_133509.4:c.171_173dup
NP_598193.2:p.(S57dup)
Likely Benign
View →
CREBBP
NM_004380.2:c.7299C>A
NP_004371.2:p.(D2433E)
VUS
View →
CALR
NM_004343.3:c.1066C>G
NP_004334.1:p.(Q356E)
VUS
View →
CALR
NM_004343.3:c.1066C>G
NP_004334.1:p.(Q356E)
Not classified
View →
GALNT12
NM_024642.5:c.460C>T
NP_078918.3:p.(R154W)
VUS
View →
BCOR
NM_017745.5:c.2265C>A
NP_060215.4:p.(Y755*)
Likely Pathogenic
View →
POLD1
NM_002691.4:c.2959del
NP_002682.2:p.(D987Tfs*58)
Likely Pathogenic
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
MSH6
NM_000179.3:c.2731C>T
NP_000170.1:p.(R911*)
Pathogenic
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
PRPF8
NM_006445.3:c.2013A>G
NP_006436.3:p.(T671=)
VUS
View →
BCOR
NM_017745.5:c.3870_3871insC
NP_060215.4:p.(K1291Qfs*84)
Likely Pathogenic
View →
STAG2
NM_001042749.1:c.2431G>T
NP_001036214.1:p.(E811*)
VUS
View →
RUNX1
NM_001754.4:c.707dup
NP_001745.2:p.(M236Ifs*25)
Pathogenic
View →
RUNX1
NM_001754.4:c.560C>T
NP_001745.2:p.(A187V)
VUS
View →
NF1
NM_001042492.2:c.2544G>A
NP_001035957.1:p.(G848=)
Benign
View →
NF1
NM_001042492.2:c.2022C>T
NP_001035957.1:p.(S674=)
Benign
View →
CUX1
NM_001202543.1:c.2598_2606dup
NP_001189472.1:p.(S868_G870dup)
Benign
View →
KMT2A
NM_005933.3:c.2040G>T
NP_005924.2:p.(S680=)
VUS
View →
DDX41
NM_016222.2:c.1479C>T
NP_057306.2:p.(S493=)
Likely Benign
View →
TERT
NM_198253.2:c.2283C>T
NP_937983.2:p.(S761=)
VUS
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
ATM
NM_000051.4:c.3332T>C
NP_000042.3:p.(L1111P)
VUS
View →
MSH2
NM_000251.3:c.2005+1G>A
NP_000242.1:p.?
Likely Pathogenic
View →
MLH1
NM_000249.4:c.1039-6dup
NP_000240.1:p.?
Benign
View →
MLH1
NM_000249.4:c.1039-6dup
NP_000240.1:p.?
VUS
View →