Project HERA
Variant repository
Every variant interpreted by the HERA pipeline, with the criteria and the sources behind each call. Free to read — no account needed.
Browse by gene
Ordered by number of pathogenic calls, then by volume.
PTEN
BRCA2
TP53
ATM
BRCA1
PALB2
MLH1
TET2
NRAS
PTPN11
MSH2
BRAF
KRAS
RUNX1
EGFR
POLE
MSH6
SMARCA4
NF1
STK11
RB1
RET
FH
FLT3
FBXW7
GNAQ
BARD1
APC
CTNNB1
CDKN2A
TSC1
PPM1D
IDH2
NF2
HRAS
ATRX
SMAD4
GNA11
SETD2
ARID1A
IDH1
PIK3CA
POLD1
DICER1
SF3B1
DNMT3A
PIK3R1
ESR1
NOTCH3
FGFR1
ZRSR2
KIT
ERBB2
BCOR
EZH2
CBL
GBA1
SMARCB1
FGFR3
GNAS
PMS2
CHEK2
TSC2
MBD4
PTCH1
NTRK1
RAD51C
ROS1
MLH3
MET
CDK4
RAD51D
CDK12
VHL
CREBBP
FGFR2
EIF1AX
CUX1
MSH3
ATR
FANCD2
BAP1
AR
DDX41
ASXL1
NOTCH2
GALNT12
NOTCH1
RNF43
NTRK2
ETV6
CYP21A2
PDGFRA
MDM2
RAD50
FOXL2
STAG2
FGF3
LRRK2
MPL
FLCN
ABL1
RECQL4
AKT1
PPP2R1A
U2AF1
SMO
CEBPA
NBN
PRKN
FBXO31
FBP1
MAX
MYD88
JAK2
SLC12A3
TERT
PRPF8
BRIP1
RAD51B
AXIN2
EZHIP
MYC
KMT2A
CDH1
BCORL1
KEAP1
MUTYH
CHEK1
FANCL
CDK6
MYCN
PHF6
SETBP1
SDHB
CCND1
FGFR4
SH2B3
GATA2
KLLN
CTNNA1
EPCAM
SDHA
LZTR1
MEN1
BMPR1A
ALK
MYCL
ERBB3
DDR2
NTRK3
SLX4
PPARG
KDR
MAP2K1
HTRA1
B3GALT6
MITF
NFE2L2
H3C2
CDKN2B
SLC2A2
CCNE1
PRKD1
CDC73
MRE11
FANCA
FANCI
RAD54L
MYH7
NTHL1
TARDBP
ANKRD26
WT1
RAF1
MAP2K2
LPL
CREB3L3
AIP
VPS13C
SPG11
SRSF2
HOXB13
POLG
COL4A1
CDK2
ERBB4
STAT3
MDM4
MAPK1
POT1
HNF1A
CCND2
CFTR
RICTOR
PKD1
PSEN1
JAK3
JAK1
GLA
PIK3CB
KMT2B
RAD51
PDCD10
MAP2K4
CACNA1C
DMP1
RPS20
H3-3A
DNAH11
ERCC2
MTOR
EGFL7
MDC1
SOX17
MYOC
TAF1
SDHD
CALR
RAD21
COL4A2
GJB2
Recently interpreted
Newest first across every gene. Pick a gene above to narrow the list.
Variant
Protein change
Classification
HNF1A
NM_000545.6:c.341G>A
NP_000536.5:p.(R114H)
Likely Benign
View →
MBD4
NM_003925.3:c.89C>T
NP_003916.1:p.(P30L)
VUS
View →
BAP1
NM_004656.4:c.37+28G>A
NP_004647.1:p.?
Likely Benign
View →
POLE
NM_006231.4:c.6748-18G>A
NP_006222.2:p.?
VUS
View →
RAD51D
NM_002878.3:c.641C>T
NP_002869.3:p.(P214L)
VUS
View →
POLE
NM_006231.4:c.6748-18G>A
NP_006222.2:p.?
VUS
View →
POT1
NM_015450.3:c.1884A>C
NP_056265.2:p.(T628=)
Benign
View →
PTCH1
NM_000264.5:c.3141T>G
NP_000255.2:p.(L1047=)
Benign
View →
ERBB2
NM_004448.3:c.2506C>A
NP_004439.2:p.(L836M)
VUS
View →
MLH1
NM_000249.3:c.1655C>T
NP_000240.1:p.(T552I)
VUS
View →
SLC2A2
NM_000340.2:c.1094G>A
NP_000331.1:p.(R365Q)
VUS
View →
SLC2A2
NM_000340.2:c.115_117del
NP_000331.1:p.(I39del)
VUS
View →
BAP1
NM_004656.4:c.376_382del
NP_004647.1:p.(S126Dfs*59)
VUS
View →
SMO
NM_005631.4:c.1886G>C
NP_005622.1:p.(R629T)
VUS
View →
RAD50
NM_005732.3:c.2033_2034dup
NP_005723.2:p.(C680Hfs*41)
Likely Pathogenic
View →
RNF43
NM_017763.5:c.252+2C>G
NP_060233.3:p.?
Likely Pathogenic
View →
SMO
NM_005631.4:c.1604G>T
NP_005622.1:p.(W535L)
Likely Pathogenic
View →
NTRK3
NM_001012338.2:c.428C>T
NP_001012338.1:p.(S143L)
VUS
View →
BAP1
NM_004656.4:c.37+28G>A
NP_004647.1:p.?
Likely Benign
View →
MSH6
NM_000179.3:c.1054G>A
NP_000170.1:p.(V352I)
VUS
View →
ATM
NM_000051.4:c.9139C>T
NP_000042.3:p.(R3047*)
VUS
View →
ATM
NM_000051.4:c.7486G>C
NP_000042.3:p.(G2496R)
VUS
View →
MBD4
NM_003925.3:c.89C>T
NP_003916.1:p.(P30L)
Likely Benign
View →
FBXW7
NM_033632.3:c.1697G>T
NP_361014.1:p.(W566L)
VUS
View →
DDR2
NM_006182.3:c.1753A>G
NP_006173.2:p.(M585V)
VUS
View →
ATM
NM_000051.4:c.7974T>C
NP_000042.3:p.(N2658=)
Likely Benign
View →
RAD51D
NM_002878.4:c.198G>T
NP_002869.3:p.(V66=)
Likely Benign
View →
PALB2
NM_024675.4:c.2580G>T
NP_078951.2:p.(E860D)
VUS
View →
SETD2
NM_014159.6:c.850del
NP_054878.5:p.(S284Pfs*17)
Likely Pathogenic
View →
BARD1
NM_000465.4:c.722C>G
NP_000456.2:p.(S241C)
Benign
View →
ATM
NM_000051.4:c.5488A>G
NP_000042.3:p.(M1830V)
Likely Benign
View →
FANCD2
NM_033084.4:c.266A>G
NP_149075.2:p.(Y89C)
VUS
View →
KLLN
NM_001126049.2:c.373C>T
NP_001119521.1:p.(R125W)
VUS
View →
TP53
NM_000546.6:c.473G>T
NP_000537.3:p.(R158L)
Pathogenic
View →
PIK3CA
NM_006218.4:c.1324G>C
NP_006209.2:p.(A442P)
VUS
View →
DICER1
NM_177438.3:c.2997T>G
NP_803187.1:p.(L999=)
Benign
View →
ERBB2
NM_004448.3:c.256A>G
NP_004439.2:p.(I86V)
VUS
View →
FGFR4
NM_213647.2:c.317C>T
NP_998812.1:p.(S106F)
VUS
View →
H3C2
NM_003537.3:c.290G>C
NP_003528.1:p.(C97S)
VUS
View →
MAPK1
NM_002745.4:c.913G>C
NP_002736.3:p.(E305Q)
VUS
View →
PIK3CA
NM_006218.3:c.2176G>A
NP_006209.2:p.(E726K)
Likely Pathogenic
View →
CBL
NM_005188.3:c.1096-1_1096delinsTT
NP_005179.2:p.?
Likely Pathogenic
View →
KIT
NM_000222.2:c.1990+8C>T
NP_000213.1:p.?
Likely Benign
View →
EZH2
NM_004456.4:c.1852-9A>C
NP_004447.2:p.?
Likely Benign
View →
TET2
NM_001127208.2:c.1413C>T
NP_001120680.1:p.(S471=)
VUS
View →
NF1
NM_000267.3:c.846G>A
NP_000258.1:p.(Q282=)
Benign
View →
EZH2
NM_004456.4:c.1966G>A
NP_004447.2:p.(A656T)
VUS
View →
CUX1
NM_001202543.1:c.2383C>G
NP_001189472.1:p.(L795V)
Likely Benign
View →
TET2
NM_001127208.2:c.2814_2815del
NP_001120680.1:p.(Q939Dfs*32)
VUS
View →
PHF6
NM_001015877.1:c.1003A>T
NP_001015877.1:p.(R335*)
VUS
View →
CHEK2
NM_007194.4:c.1597A>T
NP_009125.1:p.(T533S)
VUS
View →
PTEN
NM_000314.8:c.544T>G
NP_000305.3:p.(L182V)
VUS
View →
U2AF1
NM_006758.2:c.101C>T
NP_006749.1:p.(S34F)
Likely Pathogenic
View →
POLE
NM_006231.4:c.6531+4C>T
NP_006222.2:p.?
VUS
View →
CTNNB1
NM_001904.4:c.269G>A
NP_001895.1:p.(R90Q)
VUS
View →
PTEN
NM_000314.8:c.638C>G
NP_000305.3:p.(P213R)
VUS
View →
JAK2
NM_004972.3:c.1849G>T
NP_004963.1:p.(V617F)
Pathogenic
View →
BRCA2
NM_000059.4:c.8633-24T>G
NP_000050.3:p.?
VUS
View →
BRCA2
NM_000059.4:c.10027G>T
NP_000050.3:p.(E3343*)
VUS
View →
BRCA2
NM_000059.4:c.5661G>A
NP_000050.3:p.(T1887=)
Likely Benign
View →
BCOR
NM_017745.5:c.519C>T
NP_060215.4:p.(S173=)
Likely Benign
View →
NF1
NM_000267.3:c.2325+16C>G
NP_000258.1:p.?
Likely Benign
View →
TET2
NM_001127208.2:c.3796A>T
NP_001120680.1:p.(N1266Y)
VUS
View →
CTNNB1
NM_001904.4:c.-48-3dup
NP_001895.1:p.?
VUS
View →
CTNNB1
NM_001904.3:c.101_102delinsTT
NP_001895.1:p.(G34V)
VUS
View →
FGFR2
NM_000141.4:c.2141A>C
NP_000132.3:p.(K714T)
VUS
View →
PIK3CA
NM_006218.4:c.112C>T
NP_006209.2:p.(R38C)
VUS
View →
NRAS
NM_002524.5:c.35G>T
NP_002515.1:p.(G12V)
Pathogenic
View →
FANCL
NM_018062.3:c.580A>G
NP_060532.2:p.(I194V)
VUS
View →
MLH1
NM_000249.4:c.2041G>A
NP_000240.1:p.(A681T)
Pathogenic
View →
ATM
NM_000051.3:c.8174A>G
NP_000042.3:p.(D2725G)
VUS
View →
BRCA1
NM_007294.4:c.4189A>G
NP_009225.1:p.(R1397G)
VUS
View →
PTCH1
NM_000264.5:c.1085C>T
NP_000255.2:p.(T362I)
VUS
View →
ESR1
NM_001122740.1:c.1235G>A
NP_001116212.1:p.(R412K)
VUS
View →
RAD51C
NM_058216.3:c.923C>G
NP_478123.1:p.(A308G)
VUS
View →
FH
NM_000143.4:c.6C>T
NP_000134.2:p.(Y2=)
VUS
View →
BRCA2
NM_000059.4:c.6495G>A
NP_000050.3:p.(L2165=)
Likely Benign
View →
PMS2
NM_000535.7:c.830C>A
NP_000526.2:p.(T277K)
Benign
View →
MET
NM_001127500.3:c.3852+5T>C
NP_001120972.1:p.?
Likely Benign
View →
BRIP1
NM_032043.3:c.611C>G
NP_114432.2:p.(S204C)
VUS
View →
RAD51C
NM_058216.3:c.30G>T
NP_478123.1:p.(M10I)
VUS
View →
MDM4
NM_002393.4:c.1091G>T
NP_002384.2:p.(R364I)
VUS
View →
TP53
NM_000546.6:c.-29+121G>T
NP_000537.3:p.?
VUS
View →
ATM
NM_000051.4:c.662+13_662+14del
NP_000042.3:p.?
Likely Benign
View →
TP53
NM_000546.6:c.716A>G
NP_000537.3:p.(N239S)
Likely Pathogenic
View →
POLE
NM_006231.4:c.2778G>C
NP_006222.2:p.(E926D)
VUS
View →
RET
NM_020975.6:c.2410G>T
NP_066124.1:p.(V804L)
Likely Pathogenic
View →
GNA11
NM_002067.5:c.626A>T
NP_002058.2:p.(Q209L)
Pathogenic
View →
MYC
NM_002467.6:c.314G>A
NP_002458.2:p.(G105D)
VUS
View →
BRCA1
NM_007294.4:c.2182A>T
NP_009225.1:p.(R728*)
Pathogenic
View →
CDKN2A
NM_000077.4:c.151G>T
NP_000068.1:p.(V51F)
VUS
View →
PPP2R1A
NM_014225.5:c.739A>G
NP_055040.2:p.(T247A)
VUS
View →
GBA1
NM_000157.4:c.1279G>A
NP_000148.2:p.(E427K)
VUS
View →
TSC2
NM_000548.4:c.3581G>T
NP_000539.2:p.(W1194L)
VUS
View →
ATR
NM_001184.3:c.5459_5460insC
NP_001175.2:p.(D1821*)
Likely Pathogenic
View →
SMARCA4
NM_001128849.1:c.1333C>T
NP_001122321.1:p.(Q445*)
Likely Pathogenic
View →
SMAD4
NM_005359.5:c.1067C>T
NP_005350.1:p.(P356L)
VUS
View →
PIK3R1
NM_181523.2:c.1345_1347del
NP_852664.1:p.(L449del)
VUS
View →
CHEK1
NM_001274.5:c.1148A>T
NP_001265.2:p.(K383I)
VUS
View →
MYD88
NM_001172567.1:c.818T>C
NP_001166038.1:p.(L273P)
Pathogenic
View →